Anti-Inflamatory Effect Of Aquadest Extract Of Mango Ginger Rhizome (Curcuma mangga Val) In Swiss Webster Mice (Mus musculus)
DOI:
https://doi.org/10.62018/sitawa.v4i2.141Keywords:
Anti-inflammatory, Aqueous extract of Curcuma manga rhizome, mice, , egg white 1%Abstract
This study aims to determine the effect of aqueous extract of Curcuma mangga Val. rhizome on the anti-inflammatory response in mice (Mus musculus). The study employs an experimental method with a completely randomized design (CRD) consisting of five treatment groups: a negative control (aqueous solution), a positive control (Sodium Diclofenac 0.13 mg/kgBW), and three doses of Curcuma mangga rhizome extract (7 mg/kgBW, 28 mg/kgBW, and 56 mg/kgBW). Each treatment was administered orally 15minutes before induction with 1 % of egg white. The mice's edema volume was measuredevery hour for six hours after inflammation induction using egg white. Data were analyzed using One-Way ANOVA and Duncan's Multiple Range Test (DMRT). The One-Way ANOVA results indicated a significant effect of Curcuma mangga aqueous extract on the anti-inflammatory response, while the DMRT results showed that the 56 mg/kgBW dose had the most significant anti-inflammatory effect, with an edema inhibition percentage of 63%, closely approaching the effectiveness of Sodium Diclofenac at 62%.
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References
Amalia, D. (2016). Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Pare (Momordica charantia L.) Terhadap Mencit (Mus musculus).
Dinta, D. R. (2020). Potensi Ekstrak Etanol Biji Jengkol (Archidendron jiringa) Sebagai Antiinflamasi Terhadap Tikus Putih Jantan Galur Wistar Diinduksi Keragenan.
Fachri, H. O., Adriatmoko, W., & Astuti, P. (2018). Khasiat Ekstrak Buah Markisa Kuning (P. Edulis Sims) sebagai Antiinflamasi Dilihat dari Jumlah Monosit pada Tikus Wistar Jantan (Rattus norvegicus). Stomatognatic-Jurnal Kedokteran Gigi.
Fauziah, N. (2016). Klasifikasi Flavonoid. Universitas Al-Azhar, Jakarta.
Fitri Nugraha, D., Rizki Putri, M., & Melati, H. (2020). Uji Aktivitas Infusa Rimpang Temu Mangga (Curcuma Mangga Valeton and Zijp) Sebagai Anti Inflamasi. Jurnal Surya Medika, 10, 18–24.
Hidayati, N., Putri, A., & Rohmah, S. N. (2021). Formulasi Sirup Ekstrak Temu Mangga (Curcuma mangga Val) Dengan Variasi Konsentrasi Sorbitol Dan CMC-Na. In Jurnal Ilmu Farmasi (Vol. 12, Issue 1).
Khotimah, S. N., & Muhtadi, A. (2016). Review Artikel: Beberapa Tumbuhan Yang Mengandung Senyawa Aktif Antiinflamasi. Farmaka, 14(2), 28–40. https://scholar.google.co.id/
Mueller, M., Hobiger, S., & Jungbauer, A. (2010). Anti-inflammatory Activity Of Extracts from Fruits, Herbs and Spices. Food Chemistry, 122(4), 987–996. https://doi.org/10.1016/j.foodchem.2010.03.041
Nofita, D., & Dewangga, R. (2022). Optimasi Perbandingan Pelarut Etanol Air Terhadap Kadar Tanin pada Daun Matoa (Pometia pinnata J.R & G. Forst) Secara Spektrofotometri. Chimica et Natura Acta, 9, 102–106. https://doi.org/10.24198/cna.v9.n3.36768
Pratiwi Utami, Y., Arruansaratu, E., & Jumaetri, F. (2022). Analisis Kadar Total Alkaloid DariBeberapa Ekstrak Daun Patikala (Etlingera Elatior (Jack) R.M. Smith). In Prosiding Seminar Nasional Kefarmasian Program Studi Farmasi FMIPA Universitas Sam Ratulangi, 1.
Ramadhani, N., & Adi Sumiwi, S. (2013). Aktivitas Antiinflamasi Berbagai Tanaman Diduga Berasal Dari Flavonoid. Jurnal Famaka, 14.
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